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Duloxetine General Info

Duloxetine pills General Info

Duloxetine is a serotonin and noradrenaline reuptake inhibitor, and it is an antidepressant. The instrument of activity of Duloxetine is to smother the reuptake of serotonin and noradrenaline, bringing about expanded noradrenergic and serotonergic neurotransmission in the focal sensory system. 
The medication has a focal component for the concealment of torment, which is essentially showed by an expanded agony affectability limit in patients with torment disorder of neuropathic etiology. The substance slightly inhibits the capture of dopamine. 
It has no significant affinity for adrenergic, dopaminergic, histaminergic and cholinergic receptors. 
Duloxetine is well absorbed in the gastrointestinal tract, and absorption begins 2 hours after taking the capsule. The maximum concentration is noted after 6 hours. Food does not affect the level of the drug in the blood, but increases the time to reach the maximum concentration from 6 to 10 hours, because of the degree of absorption of the substance indirectly decreases (by about 11%).
The average clearance of Duloxetine in women is lower, but these differences have no clinical significance, so there is no need to adjust the dose depending on gender.
The situation is similar with patients of different ages (older people have a higher area under the concentration/time curve), but there is no need to change the dose. For patients with end-stage chronic renal failure on hemodialysis, the maximum concentration and area under the concentration/time curve are increased. In this regard, patients with the clinically significant impaired renal function may require a dose reduction.

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Article is posted by Helen Molina, MD

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