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Pamelor General Info

Pamelor pills General Info

Pamelor is an antidepressant with a pronounced sedative, anti-bacterial and anti-ulcer effect. Pamelor drug is produced in the form of a solution and tablets.
Pamelor is a tricyclic antidepressant, which belongs to the group of non-selective inhibitors of monoamine neuronal uptake. The mechanism of the antidepressant effect of the drug is due to the suppression of the reverse neuronal capture of catecholamines (dopamine, norepinephrine) and serotonin in the CNS.
Pamelor binds to plasma proteins by 92–96%, overcomes different barriers, including the blood-brain barrier (the same applies to nortriptyline) and the placental barrier, and is also detected in breast milk at concentrations similar to plasma.
For old people, the rate of Pamelor metabolism is reduced, which leads to a decrease in the clearance of the drug.
Liver dysfunctions can provoke a slowdown in the rate of metabolic processes and an increase in the content of amitriptyline in the blood plasma. In patients with renal dysfunction, excretion of nortriptyline and Pamelor metabolites slows down, but metabolic processes proceed in a similar way. Since Pamelor binds well to plasma proteins, its removal from the body through dialysis is almost impossible.
Indications for the use of Pamelor are: 
Schizophrenic psychosis; 
Emotional mixed disorders; 
Behavior disorders; 
Nocturnal enuresis (except that caused by low bladder tone); 
Bulimia nervosa; 
Chronic pains (a migraine, atypical facial pain, pain in cancer patients, post-traumatic and diabetic neuropathy, rheumatic pain, post-herpetic neuralgia). 
The drug is also used in gastrointestinal ulcers, for relieving headaches and preventing migraines. 
Contraindications of Pamelor are:
Severe hypertension; 
Acute diseases of the kidneys and liver; 
Atony of the bladder; 
Hypertrophy of the prostate gland; 
Paralytic intestinal obstruction; 
Pregnancy and lactation;
Age up to 6 years.


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Article is posted by Helen Molina, MD

You can get more info here: Pamelor on Wikipedia