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Loxitane General Info


Loxitane pills General Info

Loxitane is a drug that has a powerful immunosuppressive and cytostatic effect.
The immunosuppressive effect of the drug leads to more significant inhibition of delayed-type hypersensitivity, as well as to the cellular cytotoxicity (in comparison with the production of antibodies). 
The active substance inhibits the metabolism of purines, can suppress the synthesis of protein, RNA and DNA, as well as effect cell metabolism, suppress mitosis. 
In rheumatoid arthritis or other autoimmune processes, the mechanism of action of azathioprine is unknown, however, presumably, it is due to immunosuppression. As a result of the use of Loxitane (Generic), the need for taking glucocorticoids during combination therapy is reduced. 
Loxitane has the following pharmacological effects: 
Immunosuppressive (after drug withdrawal, clinical effects may persist for a long time); 
Antirheumatic (drug transforming the disease): begins to act after 6-8 weeks; 
Anti-inflammatory (with systemic lupus erythematosus and intestinal diseases): it takes effect in 4–8 weeks.
Loxitane is characterized by a high absorption from the gastrointestinal tract and a low bond to plasma proteins (30%). 
Further metabolism occurs in the liver (mainly with the participation of xanthine oxidase) and in erythrocytes, the ratio of which is different in different patients. The liver and kidneys carry out elimination. And from 1 to 2% in the form of unchanged substance. Hemodialysis is partially removed. 
According to the instructions, Loxitane is used for the following diseases: 
Idiopathic thrombocytopenic purpura; 
Myasthenia gravis; 
Rheumatoid arthritis; 
Dermatomyositis; 
Crohn's disease; 
Psoriasis; 
Autoimmune glomerulonephritis; 
Vulgar pemphigus; 
Nonspecific ulcerative colitis; 
Nodular periarteritis; 
Chronic hepatitis in the active stage; 
Systemic lupus erythematosus; 
Pyoderma gangrenous.

 

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Article is posted by Helen Molina, MD

You can get more info here: Loxitane on Wikipedia