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Adalat General Info


Adalat pills General Info

Adalat is a calcium blocker. 
Release form and composition of Adalat
The dosage form is a pack of yellow color (10 pieces in blisters, in a cardboard box there are 5 blisters). Active ingredients are nifedipine, in 1 tablet - 10 mg. 
Excipients: wheat starch, gelatin, magnesium stearate, lactose, microcrystalline cellulose PH101, talc.
Adalat is a selective blocker of slow calcium channels. The drug has antianginal, antihypertensive and vasodilating action. It reduces the current of calcium ions inside the smooth muscle cells of the peripheral and coronary arteries, as well as inside the cardiomyocytes.
In large doses, Adalat inhibits the release of calcium ions from the depot inside the cells. It reduces the number of functioning calcium channels, without affecting the time of their recovery, inactivation, and activation. 
Adalat dissociates the processes of contraction and arousal in the smooth muscles of blood vessels mediated by calmodulin and in the heart muscle mediated by troponin and tropomyosin. In therapeutic doses, the drug normalizes the transport of calcium ions through the membrane, broken in certain pathological conditions, such as arterial hypertension. 
Adalat does not affect the tone of the veins. It reduces spasm, dilates the peripheral and coronary vessels (mainly arterial), lowers blood pressure and total peripheral vascular resistance, reduces myocardial tone, afterload, and oxygen demand of the heart muscle, and prolongs the left ventricular diastolic relaxation.
Under its influence, the coronary blood flow is increased, the blood supply to the ischemic zones of the myocardium is improved, and the functioning of the collaterals is activated. 
Adalat Almost does not affect atrioventricular and sinoatrial nodes and does not have an antiarrhythmic effect. Adalat Enhances blood flow in the kidneys causes a moderate excretion of sodium in the urine. The clinical effect occurs after 20 minutes and lasts from 4 to 6 hours.

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Article is posted by Helen Molina, MD

You can get more info here: Adalat on Wikipedia