Medical Tips Online


Market research report on therapy for memory and cognition disorders

January 07, 2020

"We are pleased with the decision by the USPTO to allow this additional patent in the Crooke patent family for ssRNAi technology. There should be no doubt that the pioneering efforts at Isis have been at the forefront of new discovery for all oligonucleotide therapeutic classes," said John Maraganore, Ph.D., Chief Executive Officer of Alnylam. "As we continue our primary focus on double-stranded siRNAs, we believe that ssRNAi technology has significant potential to advance the field of RNA therapeutics broadly. While there's more to do, we are excited to combine our expertise with Isis' in advancing this promising initiative."

Issued patents in the Crooke estate already include U.S. Patent No. 5,898,031 covering RNA-containing therapeutic compounds, and U.S. Patent No. 6,107,094 covering methods of using these compounds to interfere with target RNA function, including not only interrupting protein production with single-stranded and double-stranded (siRNA) antisense compounds but also targeting other RNAs, such as microRNAs. U.S. Patent No. 7,432,250 covering methods of treating patients by administering siRNA or single-stranded RNA-like compounds; and claims in U.S. Patent No. 7,432,249 cover pharmaceutical compositions containing single-stranded RNA-like compounds. The newly allowed claims in U.S. Patent Application No. 10/281,349 cover methods of cleaving a target mRNA by a double-stranded ribonuclease (e.g. RNAi) mechanism by contacting the target mRNA with a chemically modified, single-stranded, RNA-containing therapeutic compound.

These claims further strengthen Isis' broadly applicable intellectual property estate covering RNA-based drug discovery, development, and therapeutic uses.

Following a Notice of Allowance, the process resulting in final issuance of a patent involves several administrative steps that are typically completed within a year.

Source: isispharm