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Study: Characteristics of children with OCD could help predict personalized medicine approach

July 13, 2019

The study also revealed an intriguing connection between OCD treatment outcome and family history: patients with a parent and/or sibling with OCD did six times worse in CBT than their peers without a family history of OCD. Garcia says this could be due to the nature of CBT, which requires more family support and at-home involvement than medication compliance, something that could be more difficult when a parent or other sibling is also dealing with OCD.

"Based on our findings, cognitive behavioral therapy with or without a concomitant medication is the treatment of choice for children and teens with OCD who do not have a parent or sibling who is also affected," said Garcia. "For those children with a family history, cognitive behavioral therapy in combination with a medication is probably the most effective treatment approach."

The study included 112 children between the ages of 7 and 17 with a primary diagnosis of OCD but who were not currently being treated. The group included roughly even amounts of males and females as well as younger and older children. All participants were randomly assigned to one of four treatment approaches: CBT and setraline; setraline; CBT only; and a placebo. Researchers analyzed how children responded after 12 weeks of treatment using the Children's Yale-Brown Obsessive Compulsive Scale, a clinical tool used to measure a patient's level of impairment and distress.

Source: Lifespan